Innovative Measurement of Physiological Function

Epic Research

Advancing the Understanding of Prevention and Wellness

The following resource section was developed to aid Ms. Rizzo’s mission to increase awareness and educate the industry about cellular energy and its correlation to pathological processes. In this effort, EPIC™ Research & Diagnostics, Inc. seeks to give physicians a non-invasive measurement tool for the detection of electrophysiological signals associated with the primary human body systems so they can efficiently focus their assessments and customize patient care for optimum wellness and disease prevention.

Below are some key terms and articles related to EPIC and our technology.


Glossary of Common Terms

Autonomic System – Part of the nervous system that was once thought to be functionally independent of the brain. The autonomic nervous system regulates key functions of the body including the activity of the heart muscle, smooth muscles (e.g., the muscles of the intestinal tract), and glands. Source: MedicineNet

Biophotons - Weak electromagnetic waves existing within the ultraviolet through optical range of the intensity spectrum.

Electrophysiology – The biomedical field dealing with the study of electric activity in the body. Electrophysiology includes the study of the production of electrical activity and the effects of that electrical activity on the body. Source: MedicineNet

Intercellular Communication – The transfer of information from one cell to another. Cells signal each other by direct contact with each other or by the release of a substance from one cell that is taken up by another cell. Intercellular communication is important for cells to grow and work normally. Also called cell-cell signaling and cell-to-cell signaling. NCI Dictionary of Cancer Terms.


Print Articles and Resources

Gaudesius G, Miragoli M, Thomas SP, Rohr S. Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin. Circulation Research. 2003; 93(5): 421-8.

Green LM, LaBue M, lazarus JP, Jennings JC. Reduced cell-cell communication in experimentally induced autoimmune thyroid disease. Endocrinology. 1996; 137: 2823-2832.

Huizinga JD, Liu LW, Blennerhassett MG, Thuneberg L, Molleman A. Intercellular communication in smooth muscle. Experientia. 1992; 48(10):932-41.

Meda P. Probing the function of connexin channels in primary tissues. Methods. 2000; 20(2): 232-44.

Niggli HJ, Scaletta C, Yu Y, Popp FA, Applegate LA. Ultraweak photon emission in assessing bone growth factor efficiency using fibroblastic differentiation. Journal of Photochemistry and Photobiology. 2001; 64; 62-68.

Penn RD. Ionic communication between liver cells. The Journal of Cell Biology. 1966; 29(1): 171-174.

Seppet, E., Gruno, M., Peetsalu, A., Gizatullina, Z., Phyc Nguyen, H., Vielhaber, S., Wussling, M., Trumbeckaite, S., Arandarcikaite, O., Jerzembeck, D., Sonnabend, M., Jegorov, K., Zierz, S., Striggow, F., Gellerich, F. (2009). Mitochondria and energetic depression in cell pathophysiology. International Journal of Molecular Sciences 10: 2252-2303.

Tanaka-Kunishima M, Takahashi K, Watanabe F. Cell contact induces multiple types of electrical excitability from ascidian two-cell embryos that are cleavage arrested and contain all cell fate determinants. American Journal of Physiology – Regulatory Integrative and Comparative Physiology. 2007; 293(5):R 1976-96.

Werne, C. Engelhard, K. (2007). Pathophysiology of traumatic brain injury. British Journal of Anaesthesia 99 (1): 4-9.

Zhang D, Weinbaum S, Cowin SC. Electrical signal transmission in a bone cell network: the influence of a discrete gap junction. Annals of Biomedical Engineering. 1998; 26(4):644-59.

Zoidl G, Dermietzel R. On the search for the electrical synapse: a glimpse at the future. Cell & Tissue Research. 2002; 310(2): 137-42.